Cyclizine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cyclizine hydrochloride，一种哌嗪衍生物，是一种有效的选择性组胺 H1 受体拮抗剂。Cyclizine hydrochloride 可用于恶心、呕吐和头晕的研究。

Cyclizine, sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo.(In Vitro):Cyclizine (100 μM) significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.(In Vivo):Cyclizine (1, 10 mg/kg) enhances locomotor activity of mice in a dose-dependent manner.

Cyclizine (100 μM) hydrochloride significantly inhibits nitrite accumulation and iNOS protein levels in the LPS-stimulated in RAW 264.7 cells supernatants.Cyclizine hydrochloride inhibits anti-IgE-induced histamine release from isolated human lung fragments, with an IC50 of 5.42 μM.

Cyclizine (1-10 mg/kg) hydrochloride enhances locomotor activity of mice in a dose-dependent manner.

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GPCR/G Protein

Neurokinin Receptor

Others

Others-Field

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303-25-3

302.85

C18H22N2·HCl

>98% (HPLC)

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CN1CCN(CC1)C(c1ccccc1)c1ccccc1.Cl

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(-20℃)

With Ice Pack

≥ 2 years